| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5165628 | Phytochemistry | 2012 | 13 Pages |
Abstract
⺠Echinacea species were screened for anti-inflammatory activity in RAW264.7 cells. ⺠Echinacea paradoxa var. paradoxa showed the most potent anti-inflammatory activity. ⺠Bioactivity-guided fractionation led to identification of Bauer ketones 23 and 24. ⺠They inhibited LPS-induced NO and PGE2 without reducing iNOS and COX2 protein level. ⺠Bauer ketone 24 contributed to inhibition of LPS-induced IL-1β and IL-6 secretion.
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Authors
Xiaozhu Zhang, Ludmila Rizshsky, Catherine Hauck, Luping Qu, Mark P. Widrlechner, Basil J. Nikolau, Patricia A. Murphy, Diane F. Birt,