| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5165785 | Phytochemistry | 2010 | 6 Pages |
Abstract
The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-olide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines.
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Authors
Dulcie A. Mulholland, Moses K. Langat, Neil R. Crouch, Helen M. Coley, Emily M. Mutambi, Jean-Marc Nuzillard,