| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5166151 | Phytochemistry | 2010 | 10 Pages |
Abstract
A set of bioactive constituents, the 4-component-system, were combined at the concentrations detected in a Hypericum perforatum fraction. LPS was used to model an inflammatory response in RAW 264.7 macrophages and the differentially expressed genes were compared for the fraction and 4-component-system, respectively. JAK-STAT and eicosanoid pathways were identified as being important for the Hypericum-mediated anti-inflammatory activity.
Keywords
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Organic Chemistry
Authors
Kimberly D.P. Hammer, Man-Yu Yum, Philip M. Dixon, Diane F. Birt,