Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5166271 | Phytochemistry | 2010 | 7 Pages |
Abstract
An endophytic fungus (Botryosphaeria rhodina) was isolated from the stems of the medicinal plant Bidens pilosa (Asteraceae) that is known for its anti-inflammatory, antiseptic and antifungal effects. The ethyl acetate extract of the fungal isolate exhibits significant antifungal activity as well as potent cytotoxic and antiproliferative effects against several cancer cell lines. Activity-guided fractionation resulted in the isolation of a complex of four depsidones, botryorhodines A-D and the auxin indole carboxylic acid. Botryorhodines A and B show moderate to weak cytotoxic activities and are active against a range of pathogenic fungi, such as Aspergillus terreus and the plant pathogen Fusarium oxysporum. A potential role of the endophyte in modulating fungal populations living within or attacking the host plant is discussed.
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Authors
Randa Abdou, Kirstin Scherlach, Hans-Martin Dahse, Isabel Sattler, Christian Hertweck,