Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5166291 | Phytochemistry | 2009 | 7 Pages |
Abstract
The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and their apoptosis-inducing activity investigated in human leukemia (Jurkat) cells. Further insights into the nature of this interesting apoptosis-inducing pharmacophore are described, including the requirement of both free hydroxyl groups in ring-C.
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Authors
James McNulty, Jerald J. Nair, Jaume Bastida, Siyaram Pandey, Carly Griffin,