Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5166443 | Phytochemistry | 2008 | 11 Pages |
Abstract
A polyketide synthase cDNA was isolated from callus cultures of Drosophyllum lusitanicum Link. The corresponding recombinant enzyme DluHKS accepted acetyl-CoA as starter substrate and carried out sequential decarboxylative condensations with a malonyl-CoA extender unit. The main product was identified as the hexaketide 6-(2',4'-dihydroxy-6'-methylphenyl)-4-hydroxy-2-pyrone. In addition, α-pyrones derived from three to five acetate units were detected.
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Authors
Aphacha Jindaprasert, Karin Springob, Jürgen Schmidt, Wanchai De-Eknamkul, Toni M. Kutchan,