Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways

3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the major rate-limiting step in the mevalonate pathway for sterol biosynthesis. In this study we report that regulation of HMGR activity in response to alterations of the sphingolipid and the sterol biosynthetic pathways in Arabidopsis thaliana is exerted at the post-translational level.