Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5166537 | Phytochemistry | 2009 | 5 Pages |
Abstract
A benzil, calophione A, 1-(6â²-Hydroxy-1â²,3â²-benzodioxol-5â²-yl)-2-(6â³-hydroxy-2â³-isopropenyl-2â³,3â³-dihydro-benzofuran-5â³-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and D were isolated from the roots of Tephrosia calophylla. Compounds were evaluated for cytotoxicity against RAW (mouse macrophage cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC50 of 5.00 (RAW) and 2.90 μM (HT-29), respectively.
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Authors
Seru Ganapaty, Guttula Veera Kantha Srilakshmi, Steve Thomas Pannakal, Hafizur Rahman, Hartmut Laatsch, Reto Brun,