Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae

The antiinflammatory or inflammatory properties of a series of triterpenoids and steroids isolated from Ganoderma genus were evaluated in the present paper. Compound 9 showed significant inhibitory effect on fMLP/CB-induced superoxide anion generation from rat neutrophils. Compound 10 showed significant inhibitory effects on release of β-glucuronidase stimulated with fMLP/CB from rat neutrophils and accumulation of NO2- in culture media of N9 cells in response to LPS/IFN-γ, respectively. Compound 9 was also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, it provides the first evidence that a triterpenoid, i.e.9, could protect keratinocytes from photodamage.