| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5167136 | Phytochemistry | 2007 | 9 Pages |
Abstract
The effect of the spasmolytic benzylbenzoates 1-9 from Brickellia veronicifolia on the system CaM-PDE1 was analyzed. The most active natural inhibitors were 3-5. Three series of analogs (10a-32a) of compound 4 were prepared and assayed. The most active compounds were 14a, 15a and 30a. Kinetic studies revealed that these compounds are competitive CaM antagonists.
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Authors
Blanca Rivero-Cruz, Isabel Rivero-Cruz, Rogelio RodrÃguez-Sotres, Rachel Mata,