| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5167142 | Phytochemistry | 2007 | 6 Pages |
Abstract
Bioassay-guided fractionation of the dichloromethane extract of the leaves of Vernonia staehelinoides led to the isolation of two structurally-related hirsutinolides, displaying in vitro antiplasmodial activity. The compounds lacked selectivity (cytotoxicity vs. bioactivity) but the results led to the identification of mucochloric and mucobromic acids as privileged 2(5H)-furanone substructures.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pamisha Pillay, Robert Vleggaar, Vinesh J. Maharaj, Peter J. Smith, Carmen A. Lategan, Frank Chouteau, Kelly Chibale,