| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5167164 | Phytochemistry | 2008 | 5 Pages |
Abstract
The trypanocidal activity of trans- (1) and cis- (2) methylpluviatolide isomers was evaluated against both Trypomastigote forms and gGAPDH of Trypanosoma cruzi. The cytotoxicity of the compounds and its effect on peroxide and NO production were also evaluated. Trans stereoisomers displayed trypanocidal activity and low toxicity. Only the (-)-enantiomer was active against the parasite.
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Authors
R. da Silva, J. Saraiva, S. de Albuquerque, C. Curti, P.M. Donate, T.N.C. Bianco, J.K. Bastos, M.L.A. Silva,