| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5167213 | Phytochemistry | 2007 | 7 Pages |
Abstract
The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. Crinamine 4 and haemanthamine 9 were shown to be potent inducers of apoptosis in tumour cells at micromolar concentrations. Structure-activity relationships demonstrated that both an alpha-5,10b-ethano bridge and a free hydroxyl at the C-11 position are pharmacophoric requirements of this activity.
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
James McNulty, Jerald J. Nair, Carles Codina, Jaume Bastida, Siyaram Pandey, Jenny Gerasimoff, Carly Griffin,