Semisynthesis and in vitro anticancer activities of andrographolide analogues

Article ID	Journal	Published Year	Pages	File Type
5167407	Phytochemistry	2007	9 Pages	PDF

Abstract

The semisynthesis of andrographolide derivatives, and their in vitro anticancer activities, effect on the cell cycle progression and probable mechanism(s) of action is reported.

Keywords

CDK Andrographis paniculata PBS SAR FACS TLC NCI Acanthaceae RPMI 1640 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide DMSO MTT SOM Andrographolide CNS Dimethyl sulfoxide Structure–activity relationship NSCLC Non-small cell lung cancer central nervous system Anticancer fluorescence-activated cell sorter Roswell Park Memorial Institute Phosphate-buffered saline National Cancer Institute Self-Organising Maps Semisynthesis Propidium iodide Cell cycle TLC, Thin layer chromatography cyclin-dependent kinase

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Semisynthesis and in vitro anticancer activities of andrographolide analogues

Authors

Srinivasa Rao Jada, Genevieve Suseno Subur, Charlie Matthews, Ahmad Sazali Hamzah, Nordin Haji Lajis, Mohammad Said Saad, Malcolm F.G. Stevens, Johnson Stanslas,