Biotransformations of ent-18-acetoxy-6-ketomanoyl oxides epimers at C-13 with filamentous fungi

The biotransformation of ent-18-acetoxy-6-ketomanoyl oxides, epimers at C-13, with Fusarium moniliforme and Neurospora crassa, are described. The main biohydroxylation have been introduced in both epimers at C-1 (ent-β) or C-11 (ent-α). In addition, with the 13-epi substrate N. crassa originated other minor hydroxylations by the ent-α face at C-1 or at C-12, whereas ent-11β-hydroxy or 11-oxo derivatives were achieved with the 13-normal substrate.