| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5167798 | Phytochemistry | 2007 | 8 Pages |
Abstract
Several anti-staphylococcal diterpenes were isolated from the immature cones of the conifer Chamaecyparis lawsoniana. The most active, ferruginol, caused an 80-fold potentiation of oxacillin activity against EMRSA-15, with more modest potentiation of antibiotic activity against effluxing clinical isolates of Staphylococcus aureus. The results of an efflux inhibition assay suggest that ferruginol is a weak efflux pump inhibitor.
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Authors
Eileen C.J. Smith, Elizabeth M. Williamson, Neale Wareham, Glenn W. Kaatz, Simon Gibbons,