| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5167952 | Phytochemistry | 2006 | 4 Pages |
Abstract
10-O-Demethylcephaeline (2) exhibited potent cytotoxic activity against human A549 lung carcinoma and MCF-7 breast adenocarcinoma (ED50 = 0.013 and 0.062 μM, respectively). Related compounds with different stereochemistry or hydroxy/methoxy substitution patterns were less potent or inactive. Thus, compound 2 merits attention as a cytotoxic lead for further study.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nobuko Sakurai, Kyoko Nakagawa-Goto, Junko Ito, Yojiro Sakurai, Yuka Nakanishi, Kenneth F. Bastow, Gordon Cragg, Kuo-Hsiung Lee,