| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5168038 | Phytochemistry | 2006 | 8 Pages |
Abstract
HC-toxin is a virulence factor for the plant pathogenic fungus Cochliobolus (Helminthosporium) carbonum. Specific resistance to HC-toxin and C. carbonum is controlled by Mendelian genes in maize that encode carbonyl reductases, which detoxify HC-toxin by reducing the carbonyl group of Aeo. Analogs of HC-toxin are made by at least five other fungi. Biosynthesis of HC-toxin involves at least five genes that are present in two or three functional copies over a â¼500 kb region. The genes are absent from natural toxin non-producing isolates of C. carbonum. HC-toxin is a universal inhibitor of histone deacetylases of the Rpd3/Hda1 class.
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Authors
Jonathan D. Walton,