Efficient glycosylation of unprotected sugars using sulfamic acid: A mild eco-friendly catalyst

Sulfamic acid, a mild and environmentally benign catalyst has been successfully used in the Fischer glycosylation of unprotected sugars for the preparation alkyl glycosides. A diverse range of aliphatic alcohols have been used to prepare a series of alkyl glycosides in good to excellent yield.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Sulfamic acid was used as efficient catalyst for the Fischer glycosylation. ► A series of alkyl glycosides have been synthesized in good to excellent yield. ► The reaction can be scaled-up to prepare large quantity of alkyl glycosides. ► The reaction condition is mild and eco-friendly.