Geranylated tetraoxygenated xanthones from the pericarp of Garcinia pedunculata

•Isolation of natural products from the pericarp of Garcinia pedunculata.•Structure elucidation of thirteen compounds.•Characterisation of three new geranylated tetraoxygenated xanthones, pedunxanthones D-F.•Evaluation of cytotoxicity against HeLa and NCI-H460 cells of the isolated compounds using an SRB assay.

Three new xanthones, pedunxanthones D-F (1-3), along with ten known compounds, were isolated from a chloroform extract of the pericarp of Garcinia pedunculata. Their structures were determined using spectroscopic techniques. Cytotoxicity against HeLa and NCI-H460 cells of the isolated compounds using an SRB assay was evaluated with pedunxanthone D (1) as the most active compound (IC50 24.9 ± 0.4 and 26.1 ± 1.5 μg/ml, respectively).

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