Antibacterial and cytotoxic triterpenoids from the ethanol extract of Dysoxylum densiflorum (Blume) Miq

•Three new triterpenoids were isolated from Dysoxylum densiflorum (Blume) Miq.•Two known triterpenoids were also obtained from the titled plant.•The isolated triterpenoids were evaluated in vitro for antibacterial and cytotoxic properties.•They all exhibited moderate antibacterial and cytotoxic activities.

A chemical investigation of the stem bark of Dysoxylum densiflorum (Blume) Miq. afforded three new triterpenoids, dysoxylumin A-C (1-3) together with two known compounds, 24-nor-5α,13α,14α,17α-chola-7,20,22-trien-3-one (4) and 24-norchola-1,20,22-triene-3,7-dione (5). Their structures were determined on the basis of spectroscopic analyses, including 1D-NMR, 2D-NMR, and HR-ESI-MS. The isolated components were evaluated in vitro for antibacterial properties against two Gram-positive and five Gram-negative bacteria and cytotoxicities against six tumor cell lines. As a result, triterpenoids 2-5 exhibited moderate antibacterial and cytotoxic activities.

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