Four new sesquiterpene polyol esters from Celastrus angulatus

•More information about the chemical constituents of Celastrus angulatus were given.•Four new sesquiterpene polyol esters were discovered from Celastrus angulatus.•The new sesquiterpene polyol esters were identified as β-dihydroagarofuran sesquiterpene.

Celastrus species, such as Celastrus angulatus, has been demonstrated to be very rich in natural sesquiterpene polyol esters sharing the β-dihydroagarofuran skeleton, some of which showed various biological activities. In this paper, four new sesquiterpene polyol esters, named as angulatins K-N (1-4), along with three known ones, 1β-acetoxy-9β-benzoxy-4α, 6α-dihydroxy-8α, 15-diisobutanoyloxy-2β-(α-methyl)-butanoyloxy-β-dihydroagarofuran, angulatin A, and celangulin III, were isolated from the root bark of C. angulatus. The structures of the new compounds were elucidated by extensive spectroscopic methods, mainly including HR-MS and 1D and 2D NMR techniques.

Graphical abstractFour new sesquiterpene polyol esters with β-dihydroagarofuran skeleton were isolated from the root bark of Celastrus angulatus. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses.Download full-size image