Lignans from the roots of Kadsura coccinea and their inhibitory activities on LPS-induced NO production

•Eighteen lignans were isolated from Kadsura coccinea.•Among them, three lignans were new compound and seven known lignans were found from this plant for the first time.•The isolated lignans were assayed for NO inhibitory activities by the Griess assays.•Nine of the lignans showed inhibition activity of NO-production.

Three new lignans 14-O-demethyl polysperlignan D (1), kadsurindutin E (16), coccilignan A (17), and fifteen known lignan compounds (2-15 and 18) were isolated from the roots of Kadsura coccinea. Their structures were elucidated on the basis of detailed spectroscopic analyses (IR, ESIMS, HR-ESIMS, 1D and 2D NMR, and CD). The NO production inhibitory activities of these isolated lignans were also evaluated.

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