New β-carboline and indole alkaloids from Actinomycete Actinomadura sp. BCC 24717

•The constituents of actinomycete Actinomadura sp. BCC 24717 were investigated.•Four new β-carbolines 1-4 and two new indoles 5-6 were isolated.•The structures of new compounds were elucidated and their biological activities were also evaluated.•Compound 4 exhibited cytotoxicity to Vero cells, while 6 showed antifungal activity

Four new β-carbolines 1-4 and two new indoles 5-6 were isolated together with thirteen known compounds from actinomycete, Actinomadura BCC 24717. Structures of the new compounds, 1-6, were determined by NMR spectroscopic and MS spectrometric analyses. Compound 4 exhibited cytotoxicity to Vero cells and compound 6 showed antifungal activity with IC50 35.91 μg/mL and 41.97 μg/mL, respectively.

Graphical abstractChemical structures of compounds 1, 2, and 5Download full-size image