| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5177029 | Phytochemistry Letters | 2010 | 7 Pages |
Abstract
An investigation into the keto-enol relationships in a number of hop acids has been undertaken. These provided samples to enable X-ray analyses of both natural 1 and unnatural humulone 5 to be carried out. Our results suggest that the configuration of humulone 1 may have been incorrectly assigned. An in vitro investigation into the biological activity of hop acids suggests that both humulone 1 and lupulone 2 exhibit significant activity against some human cancer cells. Our results provide evidence to show that they inhibit cell growth, induce caspase dependent apoptosis and inhibit adhesion of some cancer cells to bone tissue.
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Authors
Elizabeth Tyrrell, Roland Archer, G.A. Skinner, Kuldip Singh, Kay Colston, Catherine Driver,