| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5177060 | Phytochemistry Letters | 2012 | 5 Pages |
Abstract
Two pairs of new diastereomeric flavonolignans, hovenins A-D (1-4), were isolated from the seeds of Hovenia acerba. Their structures were established on the basis of spectroscopic methods and circular dichroism experiments. All compounds significantly inhibited NO and IL-6 generation in lipopolysaccharide (LPS)-stimulated macrophages (RAW264.7 cells) in a dose-dependent manner.
Graphical abstractDownload full-size imageHighlights⺠Four flavonolignans from the seeds of Hovenia acerba have been isolated. ⺠They are two pairs of new diastereoisomers. ⺠The anti-inflammatory activity of the isolated compounds was studied. ⺠All compounds significantly inhibited NO and IL-6 production in a dose-dependent manner.
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Authors
Xiao-Qi Zhang, Fang-Fang Xu, Lei Wang, Mei-Yan Huang, Zhong Liu, Dong-Mei Zhang, Guo-Cai Wang, Yao-Lan Li, Wen-Cai Ye,