| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5177173 | Phytochemistry Letters | 2009 | 5 Pages |
Abstract
We prepared chamavioline (7-ethyl-4-methyl-azulene-1-carbaldehyde) in three steps from 5-ethyl-2-methyl-pyridine. It inhibited cyclooxygenase-2 (57% at 1 μM). It did not inhibit cyclooxygenase-1 up to a concentration of 10 μM. After topical application, it reduced the TPA-induced mouse ear edema statistically significantly 6 h after the induction of the edema by 23 and 30% in concentrations of 0.1 and 1.0 μmol/ear. Its activity is compared to that of related azulenes. We failed to find it in Matricaria recutita L. samples.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christiane Oehler, Kerstin Bensdorf, Ronald Gust, Peter Imming,