Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity

Investigation of the crude ethanolic extract obtained from the aerial parts of Dodonaea viscosa led to the isolation of three new ent-labdane diterpenes (1-3). The structures were established on the basis of their ESI-MS, UV, IR and NMR spectral data. The crude extract, fractions and compounds were evaluated for in vitro antiviral activity against Herpes Simplex Virus type 1 (HSV-1). The crude extract showed promising antiherpes activity expressed by a selectivity index of 6.2.

Graphical abstractDownload full-size imageHighlights► Three new ent-labdane diterpenes were isolated from Dodonaea viscosa. ► All of the compounds were fully characterized by 1D and 2D NMR experiments. ► The crude ethanol extracts showed antiherpes activity.