Antiprotozoal alkaloids from Galanthus trojanus

Two new alkaloid N-oxides, 1-O-acetyldihydromethylpseudolycorine N-oxide, and 11-hydroxyvittatine N-oxide, ten known alkaloids; arolycoricidine, haemanthamine, O-methylnorbelladine, narcidine, dihydrolycorine, 8-O-demethylmaritidine, stylopine and protopine, nicotinic acid and tyramine were isolated from Galanthus trojanus A.P. Davis & N. Özhatay (Amaryllidaceae). The chemical structures of the isolates were elucidated by UV, IR, MS, CD, 1D and 2D NMR experiments. The in vitro antiprotozoal and cytotoxic potentials of the compounds were also evaluated.

Graphical abstractTwo new alkaloid N-oxides (1,2) and ten knows compounds were isolated from Galanthus trojanus. The in vitro antiprotozoal and cytotoxic potentials of the compounds were also evaluated.Download full-size imageHighlights► Two new alkaloid N-oxides were isolated from Galanthus trojanus. ► Stylopine and protopine were isolated for the first time from an Amaryllidaceae species. ► G. trojanus is an interesting source of antiprotozoal natural products.