Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5177553 | Phytochemistry Letters | 2008 | 5 Pages |
Abstract
24(R)-Ethylcholest-6-ene-5α-ol-3-O-β-d-glucopyranoside (1), along with 11 known compounds (2-12) including aporphine alkaloids, diterpenes, a steroid glycoside and a flavonoid glycoside were isolated from the leaves of Nelumbo nucifera and evaluated for their antifungal, antimalarial and for cytotoxic activities. Antifungal activity was observed for (R)-roemerine (3) and antimalarial activity for (R)-roemerine (3) and N-methylasimilobine (5). Position C-1 and C-2 of aporphine alkaloids is crucial for antimalarial activity.
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Authors
Vijai K. Agnihotri, Hala N. ElSohly, Shabana I. Khan, Melissa R. Jacob, Vaishali C. Joshi, Troy Smillie, Ikhlas A. Khan, Larry A. Walker,