Chitosan based supramolecular polypseudorotaxane as a pH-responsive polymer and their hybridization with mesoporous silica-coated magnetic graphene oxide for triggered anticancer drug delivery

•Using hybrid nanoparticle with high loading ability and enhanced hydrophilicity.•Using pH sensitive polymer shell with supramolecular polypseudorotaxane structure.•Preparation of drug nanocarrier with potential application in tumor therapy.

Chitosan based polyseudorotaxane was designed as a pH-responsive supramolecular polymeric shell around the mesoporous silica-coated magnetic graphene oxide (Fe3O4@GO@mSiO2). It was used for doxorubicin delivery at cancerous tissue in a controlled manner. The core-shell nanocarrier was formed due to electrostatic interaction between chitosan and carboxylated surface of Fe3O4@GO@mSiO2. The maximum release occurred at pH 5.5 (pH of endosomes) because the shell collapsed at this pH. The drug nanocarrier has potential application in tumor therapy due to good pH-sensitive behavior, improved solubility and high colloidal stability in biological media.

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