Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5185441 | Polymer | 2010 | 5 Pages |
Abstract
Nuclear magnetic resonance imaging (MRI) has become a powerful technique in clinical diagnostics. In this work, a new MRI contrast agent by covalently linking Gd(III) chelates to the side chain of conjugated polymer (PF-Gd) is synthesized by Suzuki cross-coupling reaction. The PF-Gd exhibits a higher relaxivity and a pronounced enhancement in contrast than that of (NMG)2-Gd-DTPA widely used for clinical diagnosis. This work should be feasible to potentially lead to a new class of imaging contrast agents.
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Related Topics
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Organic Chemistry
Authors
Qingling Xu, Litao Zhu, Minghui Yu, Fude Feng, Lingling An, Chengfen Xing, Shu Wang,