pH-responsive biodegradable amphiphilic networks

Copper-mediated azide-alkyne Huisgen's 1,3-dipolar cycloaddition is a “click” reaction that was successfully used to prepare pH-responsive, amphiphilic and biodegradable networks. Indeed, this reaction proved to be very efficient in the “one pot” grafting of amino alkyne onto azide containing poly(ɛ-caprolactone) and the cross-linking of these chains by α,ω-dialkynyl poly(ethylene oxide). The pH-controlled release of guests hosted during the cross-linking step was illustrated with an entrapped model dye.