| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5186294 | Polymer | 2007 | 6 Pages |
Abstract
The interaction of the pharmacologically important chlorpheniramine maleate (CPM) with polyanions containing sulfonate groups such as poly(sodium 4-styrenesulfonate) (PSS), poly(sodium vinylsulfonate) (PVS), and the more hydrophobic poly(sodium 2-(N-acrylamido)-2-methyl-propanesulfonate) (PAMPS) has been studied by 1H NMR. It was found that the pKa of the low-molecular weight molecule (LMWM) may be modified by its interaction with the polyanions, changing from 3 to 5, due to electric charge compensation. Interestingly, the interaction of CPM with PSS produces changes in CPM resonances, such as a general broadening and upfield shifts of the signals, and NOE effects between the LMWM and the water-soluble polymer (WSP) that indicate the presence of Ï-Ï interactions.
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Authors
Ignacio Moreno-Villoslada, Felipe González, Bernabé L. Rivas, Toshimichi Shibue, Hiroyuki Nishide,