| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5203531 | Polymer Degradation and Stability | 2009 | 8 Pages |
Abstract
In this work, a novel biodegradable pH-sensitive hydrogel based on poly(É-caprolactone) (PCL), methoxpoly(ethylene glycol) (MPEG) and methacrylic acid (MAA) was prepared by UV-initiated free radical polymerization. The resulting macromonomers and hydrogels were characterized by FTIR and/or 1H NMR. Swelling behaviour and pH sensitivity of the hydrogels were studied in detail. With increase in pH of aqueous medium from 1.2 to 7.2, swelling ratio of the hydrogels increased accordingly. The hydrolytic degradation behaviour was also investigated. The prepared biodegradable pH-sensitive hydrogel based on PCL, MPEG, and MAA might have great potential application in smart drug delivery system.
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Authors
Ke Wang, Shao Zhi Fu, Ying Chun Gu, Xu Xu, Peng Wei Dong, Gang Guo, Xia Zhao, Yu Quan Wei, Zhi Yong Qian,