| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5205361 | Polymer Testing | 2017 | 8 Pages |
This study investigated the manufacture of resorbable polycaprolactone/ibuprofen (PCL/IBP) meshes by injection molding for application in ocular orbital repair. The pore dimension sizes used demonstrate that micro-porous meshes can be manufactured by injection molding using a prototype mold. The mechanical properties were observed to be dependent on the material composition and morphology. Lower stiffness, strength and elongation at failure were observed for the 8Â mm pore sized samples. The PCL/Ibuprofen meshes initially showed a fast drug release but after 3 days the release was slow and controlled. The cytotoxicity test results of the PCL/Ibuprofen meshes indicated that the large initial quantity of Ibuprofen released was too high and resulted in cell toxicity. However, after this initial release, the PCL/Ibuprofen meshes showed a good interaction with the cells seeded on their surface. The presence of a low concentration of Ibuprofen does not negatively influence cell viability in culture.
