Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
52080 | Catalysis Communications | 2008 | 5 Pages |
Abstract
Coumarin-3-carboxylic acids and 3-acetyl-coumarins were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and 1-ethylacetoacetate or malonic acid after a 2 h reflux in ethanol in the presence of a catalytic amount of different heteropolyacids (HPAs). The less reactive 1-(2-hydroxy-phenyl)-ethanone was first reacted with alcoholic ammonia to form ketimines, which were then condensed with 1-ethylacetoacetate or malonic acid to generate 4-methyl coumarin-3-carboxylic acids and 4-methyl 3-acetyl-coumarins in moderate yields.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Majid M. Heravi, Samaheh Sadjadi, Hossein A. Oskooie, Rahim Hekmat Shoar, Fatemeh F. Bamoharram,