Article ID Journal Published Year Pages File Type
52080 Catalysis Communications 2008 5 Pages PDF
Abstract

Coumarin-3-carboxylic acids and 3-acetyl-coumarins were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and 1-ethylacetoacetate or malonic acid after a 2 h reflux in ethanol in the presence of a catalytic amount of different heteropolyacids (HPAs). The less reactive 1-(2-hydroxy-phenyl)-ethanone was first reacted with alcoholic ammonia to form ketimines, which were then condensed with 1-ethylacetoacetate or malonic acid to generate 4-methyl coumarin-3-carboxylic acids and 4-methyl 3-acetyl-coumarins in moderate yields.

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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