Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5208155 | Progress in Polymer Science | 2014 | 145 Pages |
Abstract
Replacing malfunctioning tissues with titanium-based implants has become a widespread practice spurred by population aging. Advances in biomaterials, technology and implantation protocols have led to increasing expectations on the applicability and durability of implants. The field has recently moved from a bioinert to a bioactive paradigm due to surface modifications that trigger specific responses on the surrounding tissues. Biopolymeric surface coatings have taken up a central role in these developments. The use of these and other biomimetic strategies on implants provides greater control over material-cell interactions and it is aimed at improving long-term clinical results by replicating some of the structures and mechanisms of living tissues. This review summarizes the state of the art of biomimetic implants and discusses the main directions and challenges of this field toward a more predictable and successful implant osseointegration.
Keywords
ECMMMPCCL2IGFMCPEDCFITCμCTOCPCDIBICRGDTricalcium phosphateSDFSBFWBCFGFMSCvWFRBCPEFADPGDFGAGBSPPrPNHSNPCHIFPDGFPLTTGF-ßIPNHYPpTHOPNPMNOCAOPGHGFCoCrPRGFM-CSFCXCRPVDNCPCy5N-hydroxysuccinimidePHSRNSmpBPCCsElectrochemically assisted depositionTNFISQNFκβECADHVPRed blood cellsOsseointegrationadenosin triphosphateATPadenosine diphosphateALPAlkaline phosphataseOsteoblastOsteoprotegerinOsteopontinOsteocalcinBoneOsteoclastOsteonectinHyaluronic acidEphoctacalcium phosphateOxidizedImplantinterleukinBiomimeticMicro-Computer TomographyTitaniumcluster of differentiationSMPPCsRankTIMPSurfaceEndothelial cellMesenchymal stem cellbone sialoproteinInterpenetrating networkStromal cell-derived factorHepatocyte growth factorGrowth and differentiation factorVon Willebrand factorHypoxia-inducible factormacrophage colony stimulating factorGrowth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Insulin growth factorplatelet derived growth factorfibroblastic growth factorPlatelet activation factortumor necrosis factornuclear factor kappa betaHylCalcium phosphatephosphoserinefluorescein isothiocyanateFibroblastFibronectinFibrinogenTCPLamininpolymorphonuclear leukocyteschemokine ligand 2Extracellular matrixMatrix metalloproteaseSimulated body fluidBMPIn vivo studiesAPTESTissue inhibitors of metalloproteinasesPROPAFparathyroid hormoneHydroxyapatitehydroxyprolineHydroxylysineVitronectinProteoglycanmonocyte chemotactic proteinBone morphogenetic proteinProlineplasma rich in growth factorsPlatelet rich plasmaPlateletPoly(ethylene glycol)PEGcobalt-chromecarbonyldiimidazoleCaPCollagenCalciumChondroitin sulfatecolHApwhite blood cellsGlyGlycineGlycosaminoglycanGlycoproteinephrin receptorchemokine receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ricardo Tejero, Eduardo Anitua, Gorka Orive,