Stimuli-responsive tertiary amine methacrylate-based block copolymers: Synthesis, supramolecular self-assembly and functional applications

Article ID	Journal	Published Year	Pages	File Type
5208289	Progress in Polymer Science	2014	107 Pages	PDF

Abstract

In the past decade, responsive polymers exhibiting reversible or irreversible changes in physical properties and/or chemical structures in response to external stimuli have been extensively investigated. Among them, tertiary amine methacrylate-based block copolymers represent a unique category considering their responsiveness to multiple external stimuli (e.g., pH, temperature and salts), which are essentially relevant to the biological milieu. These intriguing properties allow for their applications in a variety of fields ranging from drug or gene delivery, imaging, diagnostics, antibacterial coatings, catalysis, and bio-separations. This review article highlights tertiary amine methacrylate-based block copolymers, focusing on recent advances in the synthesis of tertiary amine methacrylate-based block copolymers with varying chemical structures and chain topologies, their supramolecular self-assembly in aqueous media as well as in the bulk state, and the emerging functional applications.

Keywords

pDNA DLS E. coli DPA CMC PGA PDMS N-Isopropylacrylamide DMA FITC Concanavalin A GTP MPC NaBH4 DEA ATRP CuCl DVS CMA P3HT UCST PAM PIC β-Cyclodextrin PPO GPC MTS QDs IEP NHS AMB ROP CCL LLA PEEP SCL PISA β-CD Cryo-TEM PTMs TDA 2-hydroxyethyl methacrylate EGDMA PLK1 AZO Lcst BPN DTBP Copper(I) chloride HPMA n-butyl methacrylate Polyisoprene EEP Pt NPs PBLG VBA DHPE POEGMA bpy CuBr Adamantine PMDETA ARGET PEGMA PGMA p-Toluenesulfonyl chloride HAuCl4 d-lactide CEMA Poly(glycerol monomethacrylate)PSSNa Poly(ethylene glycol) monomethyl ether tBMA tert-butyl methacrylate hmteta SAXS activators regenerated by electron transfer EBiB MEMA MAPTAC 1,1,4,7,10,10-hexamethyltriethylenetetramine 2VP nBMA PAPMA HEEDTA Polyacrylamide 2-(diethylamino)ethyl methacrylate 2-(Dimethylamino)ethyl methacrylate 2-vinylpyridine l-Lactide N-(2-hydroxypropyl)methacrylamide LAMA PFs pH-responsive Small interfering RNA siRNA ɛ-caprolactone Azobenzene Amphotericin B AIE ethylene glycol dimethacrylate Chloroauric acid Escherichia coli Aggregation-induced emission Atom transfer radical polymerization Photoinduced electron transfer Reversible addition-fragmentation chain transfer Apparent activation energy Con A Functional applications Copper bromide DLA Sodium borohydride Supramolecular self-assembly Polymerization-induced self-assembly Au NPs Upper critical solution temperature Lower critical solution temperature Divinyl Sulfone RAFT Kinetics Aggregation number Critical micellization concentration Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)fluorescein isothiocyanate GAMA Cryogenic transmission electron microscopy Gold nanoparticles Platinum nanoparticles quantum dots Isoelectric point NIPAM HEMA number-average molecular weight PET small angle X-ray Scattering Dynamic Light Scattering CRP Plasmid DNA Poly(3-hexylthiophene)Poly(γ-benzyl-l-glutamate)Poly(glutamic acid)Poly(propylene oxide)poly(dimethylsiloxane)Polybutadiene Polyfluorene Polypropylene Polo-like kinase 1 Polyion complex Group transfer polymerization Ring-opening polymerization Controlled radical polymerization PEG Polystyrene Pdf Core-crosslinking Gel permeation chromatography Coumarin