Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5208442 | Progress in Polymer Science | 2013 | 41 Pages |
Abstract
Stable gadolinium chelates are widely used as the contrast agents (CAs) for magnetic resonance imaging (MRI). Conjugation of the chelates onto macromolecular carriers forms macromolecular CAs (mCAs). Compared with small molecule MRI CAs, mCAs have advantages of high relaxivity and prolonged retention in blood circulation. Variants of mCAs have been synthesized and tested using animal models, showing their great potential applications in angiography, cancer imaging, kidney imaging, liver imaging, lymphatic imaging, and noninvasive visualization of drug delivery. Herein, the state of the art of mCAs, including their structures, properties, and applications is reviewed and future directions for developing mCAs are suggested.
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Authors
Jianbin Tang, Yuqi Sheng, Hongjie Hu, Youqing Shen,