Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5209008 | Progress in Polymer Science | 2007 | 20 Pages |
Abstract
Polymersomes are self-assembled shells of amphiphilic block copolymers that are currently being developed by many groups for fundamental insights into the nature of self-assembled states as well as for a variety of applications. While recent reviews have highlighted distinctive properties-particularly stability-that are strongly influenced by both copolymer type and polymer molecular weight, here we first review some of the more recent developments in computational molecular dynamics (MD) schemes that lend insight into assembly. We then review polymersome loading, in vivo stealthiness, degradation-based disassembly for controlled release, and tumor shrinkage in vivo. Comparisons of polymersomes with viral capsids are shown to encompass and inspire many aspects of current and emerging designs.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dennis E. Discher, Vanessa Ortiz, Goundla Srinivas, Michael L. Klein, Younghoon Kim, David Christian, Shenshen Cai, Peter Photos, Fariyal Ahmed,