Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5209102 | Progress in Polymer Science | 2007 | 28 Pages |
Abstract
This paper reviews recent advances in the covalent attachment of bioactive compounds to functionalized polymer surfaces including relevant techniques in polymer surface modification such as wet chemical, organosilanization, ionized gas treatments, and UV irradiation. Methods of analysis of biofunctionalized polymer surfaces, including spectral methods (X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, atomic force microscopy, and others) as well as non-spectral methods (contact angle, dye assays, biological assays, and zeta potential) are also considered. State-of-the-art techniques in covalent conjugation of bioactive compounds to the modified surfaces, such as usage of hydrophilic, bifunctional, and/or branched spacer molecules, are presented. Relevant bioconjugation reagents and chemistries are described and tabulated. Recently reported applications in areas such as biomedicine, biosensors, enzyme reactors, and textiles, all of which utilize a common set of surface bioconjugation techniques to address these diverse needs, are discussed. Finally, challenges to this emerging field of research are critically evaluated.
Keywords
BCAPDMSNH3PPyATR-FTIRPLARGDSAMθsθrAFMHUVECEVOHNHSCAHN-hydroxysuccinimideHalf widthradio frequency glow dischargeΘaPTFEEDCECMPLGAPGAIgGPCLMEMS1-ethyl-3-(3-dimethylaminopropyl)carbodiimideDNAEscaH2O Tof-SIMSWaterArgonAmmoniaethylene vinyl alcoholHeightdeoxyribonucleic acidribonucleic acidRNAUltravioletHITPolymer surface modificationOxygenimmunoglobulin Gbicinchoninic acidBiomaterialsSurface analysisBioactive compoundsELISAEnzyme-linked immunosorbent assayBiosensorsCovalent attachmentCarbon dioxideStatic contact angleReceding contact angleAdvancing contact angleHuman umbilical vein endothelial cellmicroelectromechanical systemsElectron spectroscopy for chemical analysisTime-of-Flight Secondary Ion Mass SpectrometryX-ray photoelectron spectroscopyattenuated total reflectance Fourier transform infrared spectroscopyXPSVascular Endothelial Growth Factor (VEGF)Vascular Endothelium Growth FactorExtracellular matrixSEMScanning electron microscopyatomic force microscopyNitrogenHeparin induced thrombocytopeniaContact angle hysteresisPETpoly(lactic-co-glycolic acid)poly(glycolic acid)Poly(tetrafluoroethylene)Poly(dimethyl siloxane)Poly(lactic acid)Poly(methyl methacrylate)PMMAPoly(propylene)Poly(pyrrole)Poly(caprolactone)poly(ethylene)Poly(ethylene terephthalate)Poly(ethylene glycol)Poly(styrene)Poly(urethane)PEGCO2Self assembled monolayer
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
J.M. Goddard, J.H. Hotchkiss,