| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5209696 | Reactive and Functional Polymers | 2016 | 8 Pages |
Abstract
Moreover, the results of the present study demonstrated that the effectiveness of PU-PA-1-HAP in DNA delivery is due to the HAP conjugation, which not only helps the formed complexes to escape from endolysosomes, but also opens an alternative pathway (via clathrin as opposed to via caveolae) in transfection. Therefore, the increased capability of the complexes to gain cellular entry causes their increased transfection efficiency. In contrast, PU without HAP (i.e. PU-PA-1) can only deliver DNA into cells through the caveolae-mediated pathway.
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Related Topics
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Authors
Jong Yuh Cherng, Chin Hua Lin,