Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5209811 | Reactive and Functional Polymers | 2014 | 6 Pages |
Abstract
Cellulose and amylose derivatives bearing bromobenzoate pendants were synthesized as chiral auxiliaries to create optically active biaryl compounds through Suzuki-Miyaura cross-coupling with naphthalen-1-ylboronic acids. The regioselectively substituted polysaccharide derivatives bearing 2-bromobenzoate pendants at the 6-position of the glucose unit exhibited higher diastereoselectivity than did the corresponding monosaccharide-based chiral auxiliary and the non-regioselectively substituted polysaccharide derivative bearing 2-bromobenzoates at the 2,3,6-positions. These results suggest that the chiral induction by the regioselectively substituted polysaccharide-based auxiliaries is mainly based on regular higher-order structures, such as one-handed helical structures.
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Authors
Tomoyuki Ikai, Kazuma Kimura, Katsuhiro Maeda, Shigeyoshi Kanoh,