Thermoresponsive thin hydrogel-grafted surfaces for biomedical applications

Aqueous thermoresponsive chromatography systems using PIPAAm-grafted stationary phases enable us to separate biomolecules with high biological activity. Additionally, thermoresponsive cell culture surfaces allow for the recovery of confluent cell monolayers, which have been clinically applied to ophthalmological treatments, dilated cardiomyopathy, esophageal ulcerations, periodontal disease, and cartilage injury. Furthermore, next-generation thermoresponsive cell culture surfaces for large-scale cell cultivation and the capture of specific cells have been considered a key technology for expanding small quantities of stem cells and isolating the resulting differentiated cells for therapeutic use.