Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5210160 | Reactive and Functional Polymers | 2013 | 10 Pages |
Abstract
The formation of a novel type of hydrogel that combines chemically and physically crosslinked networks in a dual-network approach is presented here. Chitosan (CHT) and chondroitin sulfate (CS) were chemically modified with glycidyl methacrylate (GMA) and then crosslinked. The chemical hydrogels (CHT- and CS-gel) were deposited in different vials filled with CS or CHT stock solutions to form the dual-network hydrogels. FTIR, TGA and XRD analyses were used to characterize the chemical and the dual-network hydrogels. The percentages of CS or CHT complexed to the CHT- and CS-gel networks were calculated from the HPLC data. SEM images and swelling assays indicated that the formation of a secondary network by polyelectrolyte complexation changes the morphologies and liquid uptake capacities of the chemical hydrogels. Hence, the data and discussion presented here enable the formation of dual-network hydrogels with very interesting properties, such as the ability to interact with charged specimens (i.e., drugs, proteins or metal ions), a desirable feature for a wide range of applications.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
André R. Fajardo, Silvia L. Fávaro, Adley F. Rubira, Edvani C. Muniz,