| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5210204 | Reactive and Functional Polymers | 2012 | 10 Pages |
Abstract
mPEG-PLLA (poly l-lactic acid) is synthesized by ring-opening polymerization of lactide and conjugation with mPEG. Sebacic acid is modified with acetic anhydride and condensed with mPEG to form mPEG-PSA (poly sebacic anhydride). The micelles formed by mPEG-PLLA are characterized by slow degradation and low drug encapsulation efficiency; on the contrary, mPEG-PSA micelles are characterized by rapid degradation but high encapsulation efficiency. They can merge into spherical micelles (Φ = 140 nm) by self-assembly in water. The mixed micelles can successfully encapsulate a typical hydrophobic drug (curcumin), and significantly improve its solubility. Experimental results show that the mixed micelles have the features of high encapsulation efficiency and slow degradation.
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Authors
Po-Liang Lai, Cheng-Chun Hsu, Tsang-Hao Liu, Ding-Wei Hong, Lih-Huei Chen, Wen-Jer Chen, I-Ming Chu,