Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5210284 | Reactive and Functional Polymers | 2013 | 4 Pages |
Abstract
A polystyrene-supported vinyl sulfone reagent was prepared and used for the solid-phase organic synthesis of 1-monosubstituted 1,2,3-triazoles via a 1,3-dipolar cycloaddition reaction with azides and subsequent cleavage from the polymer support through an elimination reaction in the presence of potassium tert-butoxide. The advantages of this method include straightforward operation, good yield and high purity of the crude products.
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Authors
Zhenzhong Huang, Ruiling Wang, Shouri Sheng, Ruyi Zhou, Mingzhong Cai,