Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5210373 | Reactive and Functional Polymers | 2012 | 8 Pages |
Abstract
A bifunctional maleimido-tetra(ethylene glycol)-poly(glycerol monoacrylate) (MAL-TEG-PGA) polymer was synthesized and used as a linker to couple functional biomolecules to iron oxide nanoparticles. The cell-penetrating peptide Tat was chosen as a model ligand and successfully conjugated to the surface of Fe3O4 nanoparticles using MAL-TEG-PGA. The Tat-conjugated Fe3O4 nanoparticles can be prepared simply by applying the linker to the iron oxide nanoparticles and then coupling the Tat peptide to the maleimide terminus or by coating the nanoparticles with a pre-coupled linker. Cell-uptake studies demonstrated that the Tat peptide was an efficient functional biomolecule to translocate iron oxide nanoparticles into the cell nucleus. Tat-conjugated nanoparticles thus prepared may be useful for drug or gene delivery.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Quan Zhang, Liang Luan, Siliang Feng, Husheng Yan, Keliang Liu,