Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5210874 | Reactive and Functional Polymers | 2007 | 8 Pages |
Abstract
The interaction of the antifolate drug pyrimethamine with chitosan derivatives, namely, chit-GLT (glutaraldehyde cross-linked chitosan gel beads) and chit-Cu (chit-GLT beads treated with copper solution) has been investigated from isothermal calorimetry at 298 and 308Â K, being studied in terms of the Avrami and pseudo-first- and second-order kinetic models. The Avrami model provided a high fitting with the experimental data. The results have pointed out the slower kinetic for pyrimethamine sorption on chit-GLT compared to chit-Cu, in agreement with the reaction time obtained from calorimetry.
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Authors
Eunice F.S. Vieira, Antonio R. Cestari, Elaine C.N. Lopes, Ledjane S. Barreto, Gilderman S. Lázaro, Luis E. Almeida,